Creutzfeldt-Jacob disease: conventional brain MR imaging fi ndings

Sporadic Creutzfeldt-Jacob disease (CJD) is a rare fatal neurodegenerative prion disease. Clinical fi ndings of CJD consist of a rapid onset dementia, myoclonus, and neurologic disorders. Defi nitive diagnosis is established with histopathologic confi rmation of brain parenchyma or autopsy materials. Periodic triphasic electroencephalography (EEG) changes and detection of 14-3-3 protein in cerebrospinal fl uid are subsequent diagnostic criteria. A case of a 63-year-old female with painful rigidity, noncooperation, disorientation and bilateral postural tremor is reported. She had hypoactive deep tendon refl exes, moderate agitation, and drowsiness without any facial asymmetry. Her speech was extremely dysarthric and unintelligible, along with akinetic mutism. Th is case of sporadic CJD is presented with magnetic resonance imaging, EEG results, clinical history and laboratory fi ndings.